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若干重要生理活性天然产物的化学与生物学研究:Total Synthesis of Lobatoside E, A Potent Antitumor Cyclic Triterpene...

  • 关键字: Lobatoside E 发布者:Chunsheng Zhu, Pingping Tang, and Biao Yu* 发布时间:2009-03-02 18:03:45 点击数: 4925次

J. Am. Chem. Soc. 2008, 130, 5872–5873.
Total Synthesis of Lobatoside E, A Potent Antitumor Cyclic Triterpene Saponin
Chunsheng Zhu, Pingping Tang, and Biao Yu*
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
 
Abstract. Lobatoside E, a novel and complex cyclic triterpene saponin showing potent antitumor activities, has been synthesized for the first time, employing a highly modular approach. The synthesis, starting with oleanolic acid, D-glucose, D-galactose, L-arabinose, and L-rhamnose, requires a total of 73 steps, with the longest linear sequence of 31 steps and in 1.2% overall yield.