BNPC生命有机化学国家重点实验室
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姓名:房鹏飞(Pengfei Fang)
职务:研究员、项目负责人
E-mail:fangpengfei@sioc.ac.cn
电话:(86) 021-54925308
传真:(86) 021-
点击数:25297

简介:

2001年9月~ 2010年6月,中国科学技术大学生命科学学院,依次获理学学士学位和哲学博士学位。2010年7月~ 2016年1月,美国Scripps研究所,助理研究员。2016年1月~至今,中国科学院上海有机化学研究所,研究员。

工作经历和教育背景:
2001年9月~ 2005年7月,中国科学技术大学生命科学学院,获理学学士学位。
2001年9月~ 2005年7月,中国科学技术大学信息科学技术学院,获工学学士第二学位。
2005年9月~ 2010年6月,中国科学技术大学生命科学学院,获哲学博士学位。
2010年7月~ 2016年1月,美国Scripps研究所,博士后助理研究员。
2016年1月~至今,中国科学院上海有机化学研究所,研究员。

研究兴趣:
1. 人源氨酰tRNA合成酶多酶复合物的化学及结构基础。
2. 结构指导的氨酰tRNA合成酶靶向的药物设计。
3. 人源GCN2信号通路的调控机理研究。

获奖及荣誉:
2001:中国科学技术大学优秀学生奖学金
2003:中国科学技术大学优秀学生奖学金
2004:中国科学技术大学优秀学生奖学金
2010:中国科学技术大学优秀毕业研究生奖学金
2013-2015:PGA-WCAD Postdoctoral Fellowships in Cancer Biology

代表性论文:

28.   Yu J, Liu Z, Liang Y, Luo F, Zhang J, Tian C, Motzik A, Zheng M, Kang J, Zhong G, Liu C, Fang P, Guo M, Razin E, Wang J. Second Messenger Ap4A Polymerizes Target Protein HINT1 to Transduce Signals in FcεRI-activated Mast Cells. Nature communications 10, 4664 (2019).

27.   Zhou XL, Chen Y, Zeng QY, Ruan ZR, Fang P, Wang ED. Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex. Nucleic acids research, 10.1093/nar/gkz588 (2019).

 26.  Hei Z, Wu S, Liu Z, Wang J, Fang P. Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex. The Journal of biological chemistry 294, 4775-4783 (2019).

 25.  Kong J, Fang P, Madoux F, Spicer TP, Scampavia L, Kim S, et al. High-Throughput Screening for Protein Synthesis Inhibitors Targeting Aminoacyl-tRNA Synthetases. SLAS discovery : advancing life sciences R & D 23, 174-182 (2018).

 24.  Wang J, Fang P, Chase P, Tshori S, Razin E, Spicer TP, et al. Development of an HTS-Compatible Assay for Discovery of Melanoma-Related Microphthalmia Transcription Factor Disruptors Using AlphaScreen Technology. SLAS discovery : advancing life sciences R & D 22, 58-66 (2017).

 23.  Tao Y, Fang P, Kim S, Guo M, Young NL, Marshall AG. Mapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry. PloS one 12, e0181869 (2017).

 22.  Fang P, Guo M. Structural characterization of human aminoacyl-tRNA synthetases for translational and nontranslational functions. Methods 113, 83-90 (2017).

 21.  Slade DJ, Fang P, Dreyton CJ, Zhang Y, Fuhrmann J, Rempel D, et al. Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design. ACS chemical biology 10, 1043-1053 (2015).

 20.  Rachmin I, Amsalem E, Golomb E, Beeri R, Gilon D, Fang P, et al. FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy. International journal of cardiology 195, 85-94 (2015).

 19.  Park H, Gonzalez AL, Yildirim I, Tran T, Lohman JR, Fang P, et al. Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10). Biochemistry 54, 3851-3859 (2015).

 18.  Mirando AC, Fang P, Williams TF, Baldor LC, Howe AK, Ebert AM, et al. Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Scientific reports 5, 13160 (2015).

 17.  Fang P, Yu X, Jeong SJ, Mirando A, Chen K, Chen X, et al. Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nature communications 6, 6402 (2015).

 16.  Fang P, Han H, Wang J, Chen K, Chen X, Guo M. Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor. Chemistry & biology 22, 734-744 (2015).

 15.  Fang P, Guo M. The Nature's Clever Trick for Making Cyclic Dinucleotide. Structure 23, 801-802 (2015).

 14.  Fang P, Guo M. Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification. Life 5, 1703-1725 (2015).

 13.  Kim DG, Lee JY, Kwon NH, Fang P, Zhang Q, Wang J, et al. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Nat Chem Biol 10, 29-34 (2014).

 12.  Zhu Y, Dai J, Zhang T, Li X, Fang P, Wang H, et al. Structural insights into the neutralization mechanism of monoclonal antibody 6C2 against ricin. The Journal of biological chemistry 288, 25165-25172 (2013).

 11.  Ofir-Birin Y, Fang P, Bennett SP, Zhang HM, Wang J, Rachmin I, et al. Structural switch of lysyl-tRNA synthetase between translation and transcription. Mol Cell 49, 30-42 (2013).

 10.  Wang J, Fang P, Schimmel P, Guo M. Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor. The journal of physical chemistry B 116, 6798-6805 (2012).

 9.   Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, et al. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS chemical biology 7, 160-165 (2012).

 8.   Xing L, Zhu Y, Fang P, Wang J, Zeng F, Li X, et al. Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli. Acta crystallographica Section F, Structural biology and crystallization communications 67, 727-729 (2011).

 7.   Wang J, Gossing M, Fang P, Zimmermann J, Li X, von Mollard GF, et al. Epsin N-terminal homology domains bind on opposite sides of two SNAREs. Proc Natl Acad Sci U S A 108, 12277-12282 (2011).

 6.   Kumar A, Park H, Fang P, Parkesh R, Guo M, Nettles KW, et al. Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 x 1 nucleotide UU internal loop conformations. Biochemistry 50, 9928-9935 (2011).

 5.   Kumar A, Fang P, Park H, Guo M, Nettles KW, Disney MD. A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome. Chembiochem : a European journal of chemical biology 12, 2140-2142 (2011).

 4.   Fang P, Zhang HM, Shapiro R, Marshall AG, Schimmel P, Yang XL, et al. Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex. Proc Natl Acad Sci U S A 108, 8239-8244 (2011). 

3.    Fang P, Li X, Wang J, Xing L, Gao Y, Niu L, et al. Crystal structure of the protein L-isoaspartyl methyltransferase from Escherichia coli. Cell biochemistry and biophysics 58, 163-167 (2010). 

2.    Fang P, Li X, Wang J, Niu L, Teng M. Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5. Biochemistry 49, 7949-7955 (2010). 

1.    Fang P, Wang J, Li X, Guo M, Xing L, Cao X, et al. Crystallization and preliminary X-ray analysis of Escherichia coli RNase G. Acta crystallographica Section F, Structural biology and crystallization communications 65, 586-588 (2009).





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