BNPC生命有机化学国家重点实验室
  您现在的位置:首页>>研究群体  

 
姓名:林亮 (Liang Lin)
职务:研究员、课题组组长
E-mail:lianglin@mail.sioc.ac.cn
电话:86-21-54925301
传真:86-21-64166128
点击数:16972
研究方向
1. 开发高通量实验方法进行蛋白质进化。
2. 天然酶的高效鉴定以及底物选择性和活性的高效进化,用于优化药物合成的关键步骤以及实用性工程酶的优化。
3. 生物体蛋白的有益优化,用于疾病(微生物感染、代谢失调、内分泌失调等)的预防和治疗。

工作经历和教育背景:
2020年6月~至今 中国科学院上海有机化学研究所,研究员
2015年11月~2020年4月
2010年9月~2015年7月 美国西北大学生物医学工程系,博士后。导师:Prof. Milan Mrksich
北京大学化学与分子工程学院,化学生物学博士。导师:陈兴教授
2006年9月~2010年7月 北京大学化学与分子工程学院,化学学士。导师:李彦教授

获奖情况
2019:第六届国际糖、脂肪和代谢失调会议荣誉证书(口头报告)
2009:第二届全国大学生创新论坛荣誉证书(口头报告)
2006:全国高中化学竞赛国家一等奖

代表性论文:

1. Benjamin Schumann*, Stacy A. Malaker, Simon P. Wisnovsky, Marjoke F. Debets, Anthony J. Agbay, Daniel Fernandez, Lauren J. S. Wagner, Liang Lin, Zhen Li, Junwon Choi, Douglas M. Fox, Jessie Peh, Melissa A. Gray, Kayvon Pedram, Jennifer J. Kohler, Milan Mrksich, and Carolyn R. Bertozzi*. Bump-and-hole engineering identifies specific substrates of glycosyltransferases in living cells. Molecular Cell 78, 1-11 (2020).

2. Liang Lin#, Weston Kightlinger#, Adam J. Hockenberry, Michael C. Jewett*, and Milan Mrksich*. Sequential glycosylation of proteins with substrate-specific N-glycosyltransferases. ACS Central Science 6, 144-154 (2020).

3. José-Marc Techner#, Weston Kightlinger#, Liang Lin, Jasmine Hershewe, Ashvita Ramesh, Matthew P. DeLisa, Michael C. Jewett*, and Milan Mrksich*. High-throughput synthesis and analysis of intact glycoproteins using SAMDI-MS. Analytical Chemistry 92, 1963-1971 (2020).

4. Weston Kightlinger, Katherine E. Duncker, Ashvita Ramesh, Ariel H. Thames, Aravind Natarajan, Jessica C. Stark, Allen Yang, Liang Lin, Milan Mrksich, Matthew P. DeLisa, and Michael C. Jewett*. A cell-free biosynthesis platform for modular construction of protein glycosylation pathways. Nature Communications 10, 5404 (2019).

5. Weston Kightlinger#, Liang Lin#, Madisen Rosztoczy, Wenhao Li, Matthew P. DeLisa, Milan Mrksich*, and Michael C. Jewett*. Design of glycosylation sites by rapid synthesis and analysis of glycosyltransferases. Nature Chemical Biology, 14, 627-635 (2018).

6. Jun Du#, Senlian Hong#, Lu Dong, Bo Cheng, Liang Lin, Bing Zhao, Ye-Guang Chen*, and Xing Chen*. Dynamic sialylation in transforming growth factor-β-induced epithelial to mesenchymal transition. Journal of Biological Chemistry 290, 12000-12013 (2015).

7. Liang Lin#, Ling Liu#, Bing Zhao, Ran Xie, Wei Lin, He Li, Yaya Li, Minlong Shi, Ye-Guang Chen, Timothy A. Springer, and Xing Chen*. Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light. Nature Nanotechnology 10, 465-471 (2015).

8. Senlian Hong, Liang Lin, Ming Xiao, and Xing Chen*. Live-cell bioorthogonal Raman imaging. Current Opinion in Chemical Biology 24, 91-96 (2015).

9. Ming Xiao, Liang Lin, Zefan Li, Jie Liu, Senlian Hong, Yaya Li, Meiling Zheng, Xuanming Duan, and Xing Chen*. SERS imaging of cell-surface biomolecules metabolically labeled with bioorthogonal Raman reporters. Chemistry-an Asian Journal 9, 2040-2044 (2014).

10. Liang Lin#, Xiangdong Tian#, Senlian Hong#, Peng Dai, Qiancheng You, Ruyi Wang, Lianshun Feng, Can Xie, Zhongqun Tian*, and Xing Chen*. A bioorthogonal Raman reporter strategy for SERS detection of glycans on live cells. Angewandte Chemie International Edition 52, 7266-7271 (2013). [Inside Cover]

11. Haibin Chu, Yihong Shen, Liang Lin, Xiaojun Qin, Ge Feng, Ziyin Lin, Jinyong Wang, Haichao Liu*, and Yan Li*. Ionic-liquid-assisted preparation of carbon nanotube-supported uniform noble metal nanoparticles and their enhanced catalytic performance. Advanced Functional Materials 20, 3747-3752 (2010).




点击次数:16972   录入时间:2020-06-03 10:48:04  【打印此页】  【返回