研究方向                                                                   
 具生物活性有机小分子的设计、合成及构效关系研究。
 氨基膦酸及磷肽的不对称合成。
 酶催化反应。

工作经历                                                                   
 1960年9月至今：中国科学院上海有机化学研究所，研究员
 1956年8月至1960年8月：中国科学院上海有机化学研究所，副研究员
 1955年9月至1956年7月：化工部医药工业管理局，副总工程师
 1948年5月至1951年6月：上海人民制药一厂，研究部技术员

教育背景                                                                   
 1944年9月至1948年5月：前国立药学专科学校，毕业。
 1951年9月至1955年9月：莫斯科全苏药物化学研究所研究生，科学副博士。

主要获奖情况                                                               
 国家自然科学奖（二等）， 一项，（1982年）。
 国家发明奖（三等）， 三项，（1987、1988、1990年）。
 国家科技进步奖（二等）， 一项，（1985年）；（三等），一项，（1987年）。
 国防科工委奖状、奖章， （1988年。）
 何梁何利奖，（2001年）。

学术任职                                                                   
 法国尼斯大学化学系客座教授（1983年9月）
 澳大利亚新南威尔斯州大学客座教授（1991年9-10月）
 法国CNRS配位化学研究所客座教授（1992年7-9月）
 美国南加州大学Roker碳氢化学研究所高级访问学者（1993年8月）
 学术刊物编委：Phosphorus, Sulfur and Silicon （1986年至今)；Solvent Extraction and Ion-Exchange （1982-2004）；Heteroatom Chemistry（1994-2003）。

代表性发表论文                                                             
1. D. Zhang, C. Yuan*; “An Enantioselective Nucleophilic Addition of α,β-Unsaturated Trifluoromethylketones Catalyzed by L-proline Derivatives” , Tetrahedron 2008, 64, 2480-2488.
2. Q. Chen, C. Yuan*; “A Facile Synthesis of Chiral 4-(tert-Butylsulfinyalmino)-2-Oxo-Phosphonates and Their Conversion into 5,5-Disubstituted 2-Benzulidene-3-oxo-Pyrolidines”; Synthesis 2008, 1085-1093.
3. A. Degterev, J. Hitomi, M. Germscheid, I. L. Ch’en, O. Korkina, X. Teng, D. Abbott, G. D. Cuny, C. Yuan, G. Wagner, S. M. Hedrick, S. A. Gerber, A. Lugovskoy & J. Yuan*. “Identification of R1P1 Kinase as a Specific Cellular Target of Necrostatins”; Nature Chemical Biology 2008, 4, 313-321.
4. D. Zhang, C. Yuan*; “A Concise and First Synthesis of α-Aminophosphinates with Two Stereogenic Atoms Leading to Optically Pure α-Amino-H-Phosphinic Acids”; Chemistry, A European Journal 2008, 14, 6049-6052.
5. Q. Chen, C. Yuan*; “Sulfinimine_medated Asymmetric Synthesis of Acyclic and Cyclic α-Amino- phosphonates”; Synthesis 2008, 2986-2990.
6. W. Zheng, A. Degterev, E. Hsu, J. Yuan, C. Yuan*; “Structure-activity Relationship Study of A Novel Necroptosis Inhibitor, Necrostatin-7”; Bioorg. & Med. Chem. Lett. 2008, 18, 4932-4935.
7. Q. Chen, C. Yuan*; “An Unexpected Ruthenium Complex and Its Unique Behavior as Catalyst in Dynamic Kinetic Resolution of Secondary Alcohols”; Chem Comm  2008, 5333-5335
8. J. Yuan, C. Yuan and D. Alexei; “Compounds, Screens and Methods of Treatment”; PCT Int. Appl 2008, Patent No. Application No. WD 2008045406, 20080417.
9. D. Zhang, C. Yuan*; “First and Highly Enantioselective Synthesis of β-Amiophosphinate with two Stereogenic Atoms and Their Conversion to Optically Pure Ethyl β-Amino-H-phosphinates”; Chemistry, A European Journal 2009 (in press)
10. Q. Chen, K. Wang and C. Yuan*; “A Chemoenzymatic Synthesis of Chiral Secondary Alcohols Bearing Sulfur-containing Functionality”; New Journal of Chemistry 2009, DOI:10.1039/b820192g
11. K. Wang, J. Li, J. Yuan, C. Yuan*; “Method of Synthesis of 3-Aryl-5,6-Substituted Thiophenopyrimin-4-Carbonyl-2-Mercaptionacetionitriles”; Chinese Patent (Issued 2008-11-5) ZL 2006 1 0117097X
12. Q. Chen, C. Yuan*; “A New and Convenient Asymmetric Synthesis of α-Amino- and α-Alkyl- α-amino-phosphonic Acids Using N-tert-Butylsulfinyl Imines as Chiral Auxiliaries”; Synthesis 2008, 3779-3786. 
13. D. Zhang, C. Yuan*; “Reaction of 1,2-unsaturated trifluoromethyl ketones and their Conversion to 1-trifluoromethylfurane derivatives”; Eur. J. Org. Chem. 2007, 23, 3916-3924.
14. K. Wang, J. Li, J.Yuan, C. Yuan*; “Structure-Activity Relationship Analysis of a Novel Necroptosis Inhibitor, Necrostain-5”; Bioorg. & Med. Chem. Lett. 2007, 17, 1455-1465. 
15. C. Yuan*, J. Li, W. Zhang; “A Facile Chemoenzymatic Method for the Preparation of Chiral 1,2-Dihydroxy-3,3,3-Trifluoropropanephosphonates”; J.Fluorine. Chem. 2006, 127, 44-47.
16. W. Zheng, C. Yuan*; “Synthesis of 3-Trifluoro-2-Hydroxy/amino-1-Fluoropropanephosphonates”; Chin. J. Chem. 2006, 24, 1170-1174.
17. D. Gong, J. Li, C. Yuan*, J. Yuan; “Synthetic study of substituted arylsulfonylphenylbenzamides” Synth. Commun. 2005, 34, 55-66.
18. C. Xu, C. Yuan*; “Candida Rugosa lipase-catalyzed kinetic resolution of β-hydroxy-β-aryl-Propionates and δ-hydroxy-δ-aryl- β-oxo-pentanoates”; Tetrahedron 2005, 61, 2169-2186.
19. C. Yuan*, Q. Chen; “Facile and efficient asymmetric synthesis of αlpha-aminoalkylphosphonic acids” Chin. J. Chem. 2005, 23, 1671-1676.
20. C. Xu, Y. Zhang, C. Yuan*; “A chemoenzymatic approach to optically active 5-hydroxy-3-oxo- carboxylates” Synlett. 2004, 3, 485-488.
21. C. Xu, Y. Zhang, C. Yuan*; “A new and convenient route to optically active 2-phosphoryl-3-oxo- 5-alkyl/aryl tetrahydrofurans and the reactions thereof” Eur. J. Org. Chem.2004, 2253-2262.
22. C. Xu, C. Yuan*; “Enzymatic synthesis of optically active 1-chloro-4-hydroxy-2-keto-alkane- phosphonates and reactions thereof” Tetrtahedron 2004,60, 3883-3892.
23. D. Gong, L. Zhang, C. Yuan*; “Synthesis of 4-(O,O-Dialkylphosphoryl)-1,3-Oxazole by Rhodium-catalyzed Hetereocycloaddition” Synth. Commun. 2004, 34, 3259-3264.
24. D. Gong, L. Zhang, C. Yuan*; “A Novel Route to 3-(O,O-Diethylphosphoryl)-2,3- dihydrofurans via Rhodium-catalyzed Hetereocycloaddition” Synth. Commun. 2004, 34, 3251-3258.
25. C. Xu, C. Yuan*; “A New Reaction System for Horner-Wadsworth-Emmons Olefination of Optically Active 4-Hydroxy-2-oxo-alkanephosphonates and 4-Hydroxy-1-chloro-2-oxo- alkanephosphonates with Aliphatic Aldehydes” Synthesis 2004, 2449-2458.
26. C. Xu, C. Yuan*; “A Facile Synthesis of Optically Active β-Amino-β-Arylethyl Phosphoates by Mitsunobu Reaction” Eur. J. Org. Chem. 2004, 4410-4415.
27. C. Xu, C. Yuan*; “An Improved Method for the synthesis of chiral Tomoxetine and fluoxines” Chin. J. Chem. 2004, 22, 775-778.
28. D. Gong, J. Li, C. Yuan*; “A New and Efficient Synthesis of Wedelolactone Derivatives” Chin. J. Chem. 2004, 22, 925-931.
29. D. Chen, P. Zhong, J. Ding and C. Yuan*; “(1RS,3aSR)-1-(chloromethyl)-1λ-5-Phospha-2,4a- Diazaperhydropentalene-1-oxide Dehydrate” Acta Cryst. 2004, E60, 237–238.
30. M.Kobori, Z. Yang, D. Gong, C. Yuan, J. Yuan*; “Wedelolactone Suppresses LPS-Induced Expression by Directly Inhibiting the IKK Complex”; Cell Death and Differetiation 2004, 11, 125-130.