BNPC生命有机化学国家重点实验室
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姓名:马大为 (Dawei Ma)
职务:副所长 博导 研究员
E-mail:madw@mail.sioc.ac.cn
电话:86-21-54925130
传真:86-21-64166128
点击数:35147

研究方向                                                                   
 具有重要生理活性的复杂天然产物的全合成及结构-活性关系研究。
 针对特殊靶点如G-蛋白偶连受体,蛋白激酶,蛋白水解酶和细胞凋亡过程的小分子调节剂的发现。
 有机合成方法学的发展和其在合成生物活性分子中的应用。

工作经历                                                                   
 1995年1月至今:中国科学院上海有机化学研究所,研究员
 1990年5月至1994年1月:美国匹兹堡大学和Mayo Clinic,博士后

教育背景                                                                   
 1984年9月至1989年7月:中国科学院上海有机化学研究所,理学博士,导师:陆熙炎教授。
 1980年9月至1984年7月:山东大学化学系,理学学士。

主要获奖情况                                                               
 求是科技基金会杰出青年学者奖(1998),
 中国青年科技奖 (1998)
 上海市十大杰出青年(2001)
 上海市科学进步一等奖(2005)
 国家自然科学二等奖 (2007)。

学术任职                                                                   
 "Journal of Medicinal Chemistry", "Journal of Organic Chemistry", "Tetrahedron/Tetrahedron Letters" and "ChemMedChem"等杂志编委

代表性发表论文                                                             
1. Qian Cai, Benli Zou, Dawei Ma*, Mild Ullmann-type biaryl ether formation reaction via combination of ortho-substituent and ligand effects, Angew. Chem. Int. Ed. 2006, 45, 1276.
2. Dawei Ma*, Yongwen Jiang, Fangping, Chen, Li-kun, Gong, Ke Ding, Yong Xu, Renxiao Wang, Aihua Ge, Jin Ren*, Jingya Li, Jia Li and Qizhuang Ye, Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted -keto carboxylic acids. J. Med. Chem. 2006, 49, 456.
3. Shouyun Yu, Xianhua Pan and Dawei Ma*, Total syntheses of halipeptins A-D, potent anti-inflammatory cyclic depsipeptides, Chem. Eur. J. 2006, 12, 6572.
4. Qian Cai, Gang He and Dawei Ma*, Mild and Non-racemization conditions for Ullmann-type diaryl ether formation between aryl halides and tyrosine derivatives, J. Org. Chem. 2006, 71, 5268.
5. Dawei Ma*, Bin Zou, Guorong Cai, Xiaoyi Hu and Jun O. Liu, Total synthesis of cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activity, Chem. Eur. J. 2006, 12, 7615.
6. Shanghai Yu, Xiaotao Pu, Tiejun Cheng, Renxiao Wang and Dawei Ma*, Total Synthesis of Clavepictines A and B and Pictamine, Org. Lett.  2006, 8, 3179.
7. Xiaotao Pu and Dawei Ma*, Facile entry to decahydroquinoline alkaloids. Total synthesis of lepadins A-E and H, J. Org. Chem. 2006, 71, 6562.
8. Xiaoan Xie, Yu Chen, Dawei Ma, Enantioselective arylation of 2-methylacetoacetates catalyzed by CuI/trans-4-hydroxy-L-proline at low reaction temperature, J. Am. Chem. Soc. 2006, 128, 16050.
9. Dawei Ma,* Shanghai Yu, Ben Li, Li Chen, Renhai Chen, Kunqian Yu, Linqi Zhang, Zhiwei Chen, Dafang Zhong, Zheng Gong, Renxiao Wang, Hualiang Jiang and Gang Pei, Synthesis and biological evaluation of 1,3,3,4-tetrasubstituted pyrrolidine CCR5 receptor antagonists. Discovery of a potent and orally bioavailable anti-HIV agent. ChemMedChem. 2007, 2, 187-193.
10. Benli Zou, Qiliang Yuan, Dawei Ma*, 1,2-Disubstituted benzimidazoles by a Cu-catalyzed cascade aryl amination-condensation process, Angew. Chem. Int. Ed. 2007, 46, 2598.
11. Gang He, Jing Wang, Dawei Ma*, Highly convergent route to cyclopeptide alkaloids. Total synthesis of ziziphine N, Org. Lett. 2007, 9, 1367.
12. Zhankui Sun, Shouyun Yu, Zuoding Ding and Dawei Ma*, Enantioselective addition of activated terminal alkynes to 1-acylpyridinium salts catalyzed by Cu-bis(oxazoline) complexes, J. Am. Chem. Soc. 2007, 129, 9300.
13. Yu Chen, Xiaoan Xie and Dawei Ma*, Facile access to polysubstituted indoles via a cascade Cu-catalyzed arylation-condensation process, J. Org. Chem. 2007, 72, 9329.
14. Benli Zou, Qiliang Yuan, Dawei Ma*, Cascade coupling/cyclization process to N-substituted 1,3-dihydrobenzimidazol-2-ones, Org. Lett. 2007, 9, 4291.
15. Shaolin Zhu, Shouyun Yu, Dawei Ma*, Highly efficient catalytic system for enantioselective Michael addition of aldehydes to nitroalkenes in water, Angew. Chem. Int. Ed. 2008, 47, 545.
16. Yu Chen, Yuji Wang, Zheming Sun, Dawei Ma*, Elaboration of 2-(trifluoromethyl)-indoles via a cascade coupling-condensation-deacylation process, Org. Lett. 2008, 10, 625.
17. Weiqing Xie, Derong Ding, Weiwei Zi, Guangyu Li, Dawei Ma, Total synthesis and Structure of Papuamide B, a potent anti-HIV marine cyclodepsipeptide, Angew. Chem. Int. Ed. 2008, 47, 2844.
18. Li Tan, Dawei Ma, Total synthesis of salinamide A, a potent anti-inflammatory bicyclic depsipeptide, Angew. Chem. Int. Ed. 2008, 47, 3614.
19. Dawei Ma, Cai Qian, Copper/amino acid catalyzed cross-couplings of aryl and vinyl halides with nucleophiles, Acc. Chem. Res. 2008, 41, 1450.
20. Jing Wang, Anqi Ma, Dawei Ma, Organocatalytic Michael addition of aldehydes to -keto-,-unsaturated esters. An efficient entry to versatile chiral building blocks. Org. Lett. 2008, 10, 5425.

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