有机合成新反应和新方法的研究及其在复杂生物活性分子合成中的应用：Copper/amino acid catalyzed cross-couplings of ...
关键字: Copper/amino acid catalyzed 发布者：Dawei Ma* and Qian Cai 发布时间：2009-03-02 21:03:10 点击数: 3876次
Acc. Chem. Res.2008, 41, 1450-1460.
Copper/amino acid catalyzed cross-couplings of aryl and vinyl halides with nucleophiles.
Dawei Ma* and Qian Cai
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Abstract: Ullmann-type coupling reactions between aryl halides and N-containing reagents, phenols and other related nucleophilic agents are very valuable transformations for organic synthesis. Their conventional reaction conditions require high reaction temperatures. We describe here that some amino acids, either as substrates or ligands, can lead Cu-catalyzed C-N, C-O, C-S, and C-C bond formations work at relatively low temperatures. An ortho-substitution effect caused by NHCOR groups is discussed. Applications of these newly developed reactions to heterocycle preparation and asymmetric synthesis are also presented.
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