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1999-2003年发表的论文 (525篇) 之二

  • 关键字: 1999-2003年发表的论文 (525篇) 之二 发布者:宣传部 发布时间:2008-12-18 08:12:46 点击数: 2438次

1999年-2003年发表的论文

    自上次评估1999年7月到2004年3月,生命有机国家重点实验室在科技部、国家自然科学基金委员会、中国科学院、上海市科委以及依托单位上海有机化学研究所的大力支持下,经过全体科研人员的努力,做出了一些在国际上有一定影响的成绩。共发表论文525篇,其中在Acc. Chem. Res., PNAS, Angew. Chem. Int. Ed., J. Am. Chem. Soc.等影响因子大于5的杂志上发表论文10篇,在影响因子为3到5之间的杂志上发表论文为76篇,在影响因子为23之间的杂志上的论文为131篇。实验室在如下5个方面取得了具有代表性阶段性成果:

 

  1. 具有抗癌、抗炎和抗疟活性的复杂天然产物的合成,结构-活性关系及作用机制研究方面的论文

  2. 一些生物大分子的选择性小分子调节剂的设计、合成及活性研究方面的论文

  3. 有机合成新反应和新方法的研究以及它们在复杂生物活性分子合成中的应用方面的论文

  4. 生物催化和生物转化方面的论文

  5. 酶和细胞色素等蛋白质的结构生物学研究方面的论文

     

 

2.一些生物大分子的选择性小分子调节剂的设计、合成及活性研究方面

论文15篇及他引数68次

序号

论 文

作 者

刊物名称

年卷

期页

他引次数

1

Stereochemically controlled cyclo-propanation of (S)-glyceraldehyde acetonide-derived olefins. Synthesis of (2S, 1'R, 2'R, 3'R)-2-(2',3'-

dicarboxycyclopropyl)-glycine.

D. Ma, Y. Cao,Y. Yang#,D. Cheng#

Org. Lett.

1999

,1,  285- 287

8

2

Asymmetric Strecker-type reaction of a- aryl ketones. Synthesis of (S)-a M4CPG, (S)-MPPG, (S)- AIDA and (S)-APICA, the antagonists of metabotropic glutamate receptors

D. Ma,H. Tian,

   G. Zou

J. Org.Chem.

1999

120-125

,64,

16

3

General and stereospecific route to 9-substituted, 8,9-disubstituted, and 9,10-disub-stituted analogues of benzolactam-V8.

D. Ma, W. Tang,

A.P.Kozikowski#, N. E. Lewin#,   P. M. Blumberg#

J. Org.Chem.

1999

,64, 6366- 6373

2

4

Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells.

D. Ibarreta#, M.Duchen#,

D. Ma, L. Qiao#, A.P. Kozikowski#,R. Etcheberrigaray#

NeuroReport

1999

, 10, 1035- 1040

2

5

Synthesis and protein kinase C binding activity of benzolactam-V7.

D. Ma, G. Wang,S. Wang,# A. P. Kozikowski#,P. M. Blumberg#

Bioorg. Med.

Chem. Lett.

1999

1371- 1374

, 9,

3

6

Conformationally constrained analogues of L-glutamate as subtype-selective modulators of metabo-tropic glutamate receptors

D. Ma

Bioorg.Chem.

1999

27,20-34

,

2

7

Synthesis of (2S,1’R,2’R,3’R)-2-(2’,3’-Dicarbxycyclo-propyl)-glycine via the Stereo-chemically Controlled Cyclo- propanation of (S)-Gly-

ceraldehyde Acetonide-Derived Enones

D. Ma, Y. Cao,

   W. Wu, Y. Jiang

Tetrahedron

2000

, 56, 7447-7456

3

8

Synthesis of (S)-

?-Cyclopropyl-4- phosphonophenylglycine

D. Ma,W. Zhu

J. Org.Chem

2001

, 66, 348 ~350

12

9

Studies toward the Total Synthesis of Clavulactone

Q. Zhu, L.Qiao,

Y. Wu, Y. Wu

J. Org.Chem.

2001

,66, 2692- 2699

3

10

Recent Advances in the Discovery of Protein Kinase C Modulators Based on the Structures of Natural Protein Kinase C Activators

D. Ma

Current

Chemistry

Med.

2001

191-202

,8

5

11

Synthesis of 7,8-Disubstituted Benzolactam-V8 and Its Binding to Protein Kinase C

D. Ma, T Zhang,  G. Wang, A.P. Kozikowski#,

N. E.Lewin#,P. M. Blumberg#

Bioorg. &

Med. Chem.Lett.

2001

99-101

,11

6

12

Structural Basis of RasGRP Binding to HighAffinity PKC Ligands

S. Rong,#I. J. Enyedy,#L.Qiao,   #L.Zhao

,# D. Ma*,L.L.Pearce,   #P. S.Lorenzo, #J.C.Stone, #P. M.Blumberg#S.Wang, A.P.Kozikowski#

J. Med.Chem

2002

853-860

, 45,

3

13

Asymmetric synthesis of (S)-1-amino- indan-1,5- dicarboxylic acid and related analogues via intramolecular acylation of enantiopure a ,a-di- substituted amino acid

D. Ma, K. Ding#H. Tian, B. Wang#

   D. Cheng#

Tetrahedron:

Asymmetry

2002

961-969

, 13,

2

14

Synthesis of 7-Substituted Benzolactam-V8s and their Selectivity for the Protein Kinase C Iso- zymes

D. Ma, G. Tang,

  A. P.Kozikowski

Org.Lett.

2002

2377-2380

,4,

1

15

Synthesis of a New Conformation-Constrained L-Tyrosine Analogue as a Potential Scaffold for SH2 Domain Ligands

F Liu, H. Zha

,   Z. Yao

J. Org.Chem.

2003

,68, 6679-6684

 

成果2前期研究工作部分论文8篇及他引数89次

 
 

Asymmetric synthesis of (+)-4CPMG, a selective antagonist of metabotropic glutamate receptors

D. Ma,H. Tian

Tetrahedron: Asymmetry,

1996,

7, 1567–1570

6

2

Stereoselective synthesis of (1S,3R)-ACPD, a selective agonist of metabotropic glutamate receptors

D. Ma, J. Ma

,   L. Dai

Tetrahedron: Asymmetry

1997

825 -827

,8,

15

3

Modeling, chemistry, and biology of the ben- zolactam analogues of ILV. 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKC??and disco- very of an ILV analogue of improved isozyme selectivity

Alan. P. K. ,Sm Wang,

D Ma, J.Yao, S. A. Robert, I. Glazer, K. Bogi, S.Modarres, P. M. Blumberg

J. Med. Chem.

1997

,40, 1316-1326

 

19

4

Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic receptor antagonists

D.Ma, H. Tian, H. Sun, A. P. Kozikowski, S. Pshenichkin, J. T. Wroblewski

Biorg. & Med. Chem. Lett

1997,

1195-1198

7,

 

15

5

Synthesis of (2S,1’S,2’S)-2-methyl-2-(carbo-xycyclopropyl)glycine and (S)-2- amino-2-methyl-4-phosphonobutyric acid from L-alanine

D. Ma, Z. Ma, J.Jiang, Z.Yang, C.Zheng

Tetrahedron: Asymmetry

1997

889-893

,8, 

 

7

6

Facile synthesis of (2S,1’S,2’S)-2-(carboxycyclo- propyl)glycine, an isotype-selective agonist of metabotropic glutamate receptors

D. Ma, Z. Ma

Tetrahedron Lett.

1997

,38, 7599-7602

 

11

7

Stereoselective synthesis of (S)-MPPG, (S)-MTPG and (S)-(+)-a-M4CPG from (R)-4-

hydroxyphenylglycine

D. Ma , H. Tian

J. Chem. Soc. Perkin Trans. 1

1997

3493-3496

,

 

11

8

Synthesis and biological evaluation of two analogues of (S)-a-methyl-3- carboxyphenylalanine

D. Ma, Z.Ma, A P. Kozikowski, S. Pshenichkin, J. T. Wroblewski

Biorg. & Med. Chem. Lett

1998

,8, 2447- 2450

5