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1999-2003年发表的论文 (525篇) 之一

  • 关键字: 1999-2003年发表的论文 (525篇) 发布者:宣传部 发布时间:2008-12-18 08:12:58 点击数: 2347次

1999年-2003年发表的论文

    自上次评估1999年7月到2004年3月,生命有机国家重点实验室在科技部、国家自然科学基金委员会、中国科学院、上海市科委以及依托单位上海有机化学研究所的大力支持下,经过全体科研人员的努力,做出了一些在国际上有一定影响的成绩。共发表论文525篇,其中在Acc. Chem. Res., PNAS, Angew. Chem. Int. Ed., J. Am. Chem. Soc.等影响因子大于5的杂志上发表论文10篇,在影响因子为3到5之间的杂志上发表论文为76篇,在影响因子为23之间的杂志上的论文为131篇。实验室在如下5个方面取得了具有代表性阶段性成果:

 

  1. 具有抗癌、抗炎和抗疟活性的复杂天然产物的合成,结构-活性关系及作用机制研究方面的论文

  2. 一些生物大分子的选择性小分子调节剂的设计、合成及活性研究方面的论文

  3. 有机合成新反应和新方法的研究以及它们在复杂生物活性分子合成中的应用方面的论文

  4. 生物催化和生物转化方面的论文

  5. 酶和细胞色素等蛋白质的结构生物学研究方面的论文

     

 

1.具有抗癌、抗炎和抗疟活性的复杂天然产物的合成,结构-活性关系及作用机制研究方面

论文62篇及他引数246               

 

论 文

 

作 者

 

刊物名称

年卷

期页

他引次数

1

Interaction of Qinghaosu (Artemisinin) with Cys- teine Sulfhydryl Mediated by Traces of Non- Heme Iron

Y. Wu, Z.Yue#,

  Y. Wu

Angew.Chem. Int.Ed.

1999

, 38, 2580- 2582

20

2

The First Synthesis of Tonkinecin, an Annonaceous Acetogenin with a C-5 Carbinol Center

T. Hu,Q.Yu

, Q. Li,Y. Wu,Y. Wu

Org. Lett.

1999,

1, 399- 401

12

3

First Total Synthesis of an Exceptionally Potent Antitumor Saponin, OSW-1

S. Deng

,  B. Yu,Y. Lou,Y. Hui

J. Org.Chem.

1999

,64, 202- 208

20

4

Total Synthesis of (10R)- and (10S)-Coros-solin: Determination of the Stereochemistry at C-10 of the Natural Corossolin and the Differential Toxicity toward Cancer Cells Caused by the Configuration at C-10

Q. Yu

, Z.Yao,X. Chen,Y. Wu

J. Org.Chem.

1999

, 64, 2440-2445

12

5

The First Synthesis of Optically Pure Biscar- Bazoles and Determination of Their Absolute Configurations

G. Lin,

  A. Zhang

Tetrahedron Lett.

1999

40

, 341-344
,

7

6

A new concise stereoselective method for the preparation of a b-hydroxyfurfury- lamine derivative and synthesis of 1- deoxyazasugar isomers

L. Liao,Z. Wang

#, H.Zhang,  W. Zhou

Tetrahedron: Asymmetry

1999

, 10, 3649- 3657

9

7

The first total synthesis of 4- deoxyannomontacin

Q Yu

, Y.Wu, H Ding  Y. Wu,

J. Chem.Soc.

Perkin Trans.1

1999

1183- 1188

,

14

8

Synthesis, iron(II)-induced cleavage and in vivo antimalarial efficacy of 10-(2- hydroxy-1-naph-thyl)- deoxoqinghaosu (-deoxoartemi-sinin)

D. Wang

, Y. Wu, Y. Wu, Y Li,#F Shan#

J. Chem.Soc.

Perkin Trans.1

1999

1827- 1831

12

9

Interaction of biomolecules with qinghaosu (artemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism

Y.Wu,H.Chen, K Jiang#, Y Li#,FShan#, D. Wang, Y. Wang#, W. Wu, Y. Wu, Z. Yao, Z.Yue#, C. Zhou#

Pure Appl.Chem.

1999,

71, 1139- 1142

3

10

Enantiopure Simple Analogues of Annona-ceous Acetogenins with Remarkable Selective Cytotoxicity towards Tumor Cell Lines

B. Zheng

,Y. Wu,Q. Yu, Y. Wu,Y Li#, X.Chen#

Angew. Chem.

Int. Ed.

2000

,39, 1934- 1937

2

11

Polyether Mimics of Natural Occurring Cytotoxic Annonaceous Acetogenins

Z. Yao,H. Wu, Y. Wu

J. Med.Chem.

2000

,43, 2484- 2487

4

12

A Possible Antimalarial Action Mode of Qinghaosu (Artemisinin) Series Compounds. Alkylation of Reduced Glutathione by C-centered Primary Radical Produced from Antimalarial Compound Qinghaosu and 12-(2,4-dimethoxy-1-phenyl)- deoxoqinghaosu

D. Wang

, Y. Wu

Chem.Commun.

2000

, 22, 2193- 2194

8

13

An Efficient and Convenient Approach to the

Total Synthesis of Sphingofungin

D. Liu

,B. Wang,G. Lin

J. Org. Chem.

2000

,65, 9114~ 9119

12

14

The First Total Synthesis of Annonacin, the Most

Typical Monotetrahydrofuran An-nonaceous Acetogenins

T. Hu

, Y. Wu,Y. Wu

Org. Lett.

2000

, 2, 887-889

6

15

Synthesis and absolute stereochemistry of the acyl moiety of Quillajasaponin

X. Zhu

, B Yu,Y. Hui, R.Higuchi#,T. Kusano#,T. Miyamoto#

Tetrahedron

Lett.

2000

717-719

, 41,

2

16

Enantioselective construction of oxidized tryptophan fragment of proteasome inhibitors TMC-95A and TMC-95B

D. Ma,Q. Wu

Tetrahedron Lett.

2000

,41, 9089- 9093

10

17

Synthesis of Optically Pure Clausenamine-A and its Demethoxylated Analogs

G. Lin,A. Zhang

Tetrahedron

2000

,56, 7163-7171

4

18

Chemical and electro-chemical reduction of qinghaosu(artemisinin)

W. Wu,Y. Wu

J. Chem.Soc.,

PerkinTrans.1

2000

4279- 4283

1

19

The first synthesis of Clausenamine-A and Cytotoxic Activities of Three Biscarbazole Analogues Against Cancer Cells

A. Zhang

,G. Lin

Bioorg. &Med. Chem.Lett.

2000

,10, 1021-1023

2

20

Synthesis of glycosides bearing the disaccharide of OSW-1 or its 1® 4- linked analogue and their antitumor activities

X. Ma

,B.Yu, Y. Hui, D. Xiao#,J.Ding#

Carbohydr.Res.

2000

, 329, 495-505

3

21

First Total Synthesis of Martinellic Acid, a Naturally Occurring Bradykinin Receptor Antago-nist

D. Ma, C. Xia,J. Jiang,J. Zhang

Org.Lett.

2001

, 3, 2189- 2191

13

22

New Insights into the Degradation of Qing-haosu (Artemisinin) Mediated by Non-Heme-Iron Chelates, and Their Relevance to the Antimalarial Mechanism

Y. Wu,Z. Yue#,H. Liu

Helv.

Chim. Acta

2001

928-932

, 84,

3

23

A new highly stereoselective construction of the sidechain of squalamine through improved Sharpless catalytic asymmetric dihydroxylation

X. Zhou,

F. Cai#,W.Zhou

Tetrahedron

Lett.

2001

,42, 2537- 2539

4

24

Synthesis of the biaryl moiety of the proteasome inhibitors TMC-95 via a ligandless Pd(OAc)2-catalyzed Suzuki-coupling reaction

D. Ma,Q. Wu

Tetrahedron

Lett.

2001

,42, 5279- 5281

12

25

A new highly stereoselective synthesis of cerebrosterol, an agonist of the nuclear receptor LXRs

X. Zhou,

W. Zhou

Tetrahedron

2001

,57, 8291- 8296

1

26

Synthesis of (± )-3,3’-bis(4-hydroxy-2H-benzopyran): a Literature correction

R. Hong, J. Feng#,

R. Hoen#, G. Lin

Tetrahedron

2001

,57, 8685- 8689

2

27

Further evidence for the participation of primary carbon-centered free radicals in the antimalarial action of theqinghaosu (artemisinin) series of compounds

D. Wang,

Y. WuY. Wu, J Liang# Y Li#

J. Chem.Soc., Perkin Trans.1

2001

605-609

6

28

Synthesis of OSW-1 Analogues and a Dimer and Their Antitumor Activities

X. Ma

,B.Yu, Y. Hui,Z. Miao#J.Ding#

Bioorg. &Med. Chem.Lett.

2001

,11, 2153~ 2156

2

29

Synthesis of steroidal glycosides bearing the disaccharide moiety of OSW-1 and their antitumor activities

X. Ma

,B.Yu, Y. Hui,Z. Miao#J.Ding#

Carbohydr.Res.

2001

, 334, 159~164

2

30

How Might Qinghaosu (Artemisinin) and Related Compounds Kill the Intraerythrocytic Malaria Parasite? — A Chemist’s View

Y. Wu

Acc. Chem.

Res.

2002

,35, 255-259

13

31

Mimicking of Annonaceous Acetogenins:

Enantioselective Synthesis of a (4R)- Hydroxy Analog Having Potent Antitumor Activity

S. Jiang,Z. Liu, G. Shen,B.Zeng, X. Cheng,

Y. Wu, Z. Yao

J. Org.Chem

2002,

67, 3404-3408

2

32

Enantioselective Synthesis of (2R,3R)-3- Hydro- xy-3-methylproline, A Novel Amino Acid Found in Polyoxypeptins

D. Qin

,H. Zha,Z. Yao

J. Org.Chem

2002

,67, 1038-1040

3

33

Total Synthesis of (

±)-Martinelline

C. Xia,

L. Heng #,D.Ma

Tetrahedron

Lett.

2002

,43, 9405-9409

4

34

Synthesis of Fully Protected (2S,3R)-N-(1’,1’-dimethyl-2’-propalenyl)-3- hydroxytryptophan from Tryptophan

S

. Wen,H. Zhang, Z. Yao

Tetrahedron

Lett.

2002

,43, 5291-5294
 

35

The first stereoselective synthesis of orostanal, a novel abeo-sterol inducing apoptosis in leukemia cells

B

. Liu, W.Zhou

Tetrahedron

Lett.

2002

,43, 4187-4189
 

36

A Stereoselective synthesis of squalamine

X.Zhou,F. Cai#,W.Zhou

Tetrahedron

2002

,58, 10293-10299
 

37

Sharpless AD-based strategy towards the g -me- thyl Butenolides unit of Acetogenins: enan- tioselective synthesis of Butenolides I and II with mosquito larvicidal activity

Y. He

, H.Yang, Z. Yao

Tetrahedron

2002

,58, 8805-8810

1

38

Efficient Synthesis of the Hexasac- charide Fragment of Landomycin A: Using Phenyl 2,3-O-Thio-nocarbonyl-1-thio- glycosides as 2-Deoxy-

b-glycoside Precursors

B. Yu,

   P. Wang

Org. Lett.

2002

, 4, 1919-1922

1

39

Total Synthesis of Microsclerodermin E

J. Zhu

,   D. Ma

Angew. Chem. Int. Ed.

2003,

42, 5348-5351
 

40

An over Four Millennium Story behind Qinghaosu (artemisnin) A Fantastic Antimalarial

Drug from a Traditional Chinese Herb

Y .Li#, Y.Wu

Current Med. Chem.

2003

,10, 2197-2230

1

41

Studies on Mimicry of Naturally Occurring Annonaceous Acetogenins: Non-THF Analogues Leading to Remarkable Selective Cytotoxicity against Human Tumor Cells

B. Zeng

, Y. Wu,S.Jiang, Q. Yu,Z. Yao, Z.Liu, H. Li, Y. Li#, X. Chen#,Y. Wu

Chem.

Eur. J.

2003

282-290

,9,

1

42

A Concise and Stereoselective Synthesis of Squalamine

D. Zhang, F. Cai#, X. Zhou

,W.Zhou

Org.Lett.

2003,

5, 3257-3259
 

43

Synthesis of An Oxazoline Analogue of

Apratoxin A

B. Zou, J. W

ei,G. Cai, D. Ma

Org.Lett.

2003,

5, 3503-3506
 

44

Preparation of syn-

?-Hydroxy-?-Amino Esters via an Intramolecular Hydrogen Bond Directed Diastereoselective Hydrogenation. Total Synthesis of (3S,4aS,6R,8S)-Hyperasine

W. Zhu

D. Ma

,

Org. Lett.

2003,

5, 5063-5066
 

45

Induction of Cell death of gastric cancer cells by a modified compound of annonaceous acetogenin family

G. Huang, S. Jiang

, Y. Wu,Z. Yao, J. Wu

 

ChemBio.Chem.

 

2003

,4, 1216-1221
 

46

Aromatic Nucleophilic Substitution or CuI- Catalyzed Coupling Route to Martinellic Acid

D. Ma, C. Xia, J. Jiang, J. Zhang,W.Tang

J. Org.Chem.

2003,

442-451

68,

5

47

Studies on the Synthesis of (2S, 3R)-3-Hydroxy-3-methylproline via C2-N Bond Formation

J.Shen, Qin, D, H.Zhang

, Z. Yao

J. Org.Chem.

2003

,68, 7479-7484
 

48

Molecular diversity from tonghaosu analogs: Selective reduction of the endo-cyclic double bond of tonghaosu analogs and the synthesis of cyclopentenone derivatives

B. Yin, J.Fan, Y

.Gao, Y.Wu

Synlett.

2003

399-401

,3,
 

49

Synthetic Studies Towards Phprboxazole B

Stereoselective Synthesis of the C3- C19 Bisoxane Oxazole Fragment

D. Zhang

W. Zhou

,

Synlett.

2003,

12, 1817-1821
 

50

Novel asymmetric total synthesis of the natural(+)-6-epicastanospermine

H. Zhang

,P. Xia, W.Zhou

Tetrahedron

2003,

59, 2015-2020

1

51

The first stereoselective synthesis of orostanal isolated from a marine spone Stelletta hiwasaensis

B. Liu

, W.Zhou

 

Tetrahedron

2003,

59, 3379-3384
 

52

A novel concise total synthesis of (+)- lentiginosine

Z. Feng

,  W. Zhou

Tetrahedron Lett.

2003,

44, 497-498

3

53

An Efficient Enantioselective Synthesis of the Acyl Side Chain of Polyoxypeptins

D.Qin,

,  Z. Yao

Tetrahedron Lett.

2003

,44, 571-574
 

54

A new synthesis of tanikolide

H. Zhai

, Q. Chen, J. Zhao,S.Luo, X. Jia

Tetrahedron Lett.

2003

,44, 2893-2894
 

55

Stereoselective synthesis of the C21-C27 fragment of the phorboxazoles

B. Liu

,   W. Zhou

Tetrahedron Lett.

2003,

44, 4933-4935

3

56

A general and efficient route to enantioselective synthesis of pumiliotoxin A alkaloids via a common key intermediate

B. Wang,K. Fang

,    G. Lin

Tetrahedron Lett.

2003

,44, 7981-7984
 

57

Studies on the synthesis of phorboxazole B:stereoselective synthesis of the C28- C46 segment

D. Li

, Y. Tu#,G. Lin, W. Zhou

Tetrahedron Lett.

2003

, 44, 8729-8732
 

58

Molecular Diversity of Tonghaosu, Synthesis of Lactam Containing Tonghaosu Analogs

B..Yin,

, Z. Yang, T. Hu, , Y. Wu

Synthesis

2003

, 1995-2000
 

59

Chemistry of Tonghaosu Analogs, Novel Acid Catalyzed Nucleophilic Addition to the Dienyl Acetal System

B. Yin,

, W. Wu, T. Hu, Y. Wu

Eur. J. Org. Chem.

2003

, 4016-4022
 

60

Study on the Mechanism of Action of Artemether against Schistosomes: The Identifi-cation of Cysteine Adducts of Both Carbon-centered Free Radicals Derived from Artemether

W. Wu, Y. Chen, Z. Zhai, S. Xiao,Y. Wu

Bioorg. Med. Chem. Lett.

2003

, 13, 1645-1647
 

61

Cleavage of Qinghaosu (Artemisinin) Induced by Non-Iron Transition-Metal Ions in the Presence of Excess Cysteine

Y. Wu,    H. Liu

Helv. Chim. Acta.

2003

, 86, 3074-3080
 

62

Synthesis of monomethylated dioscin derivatives and their antitumor activities

M. Li

, X. Han#,B. Yu

Carbohydr. Res.

2003

, 338, 117-121
 

成果1前期研究工作部分论文8篇及他引数130次          

1

A facile synthetic approach to a group of stru- cturally typical diosgenyl saponin. S

S. Deng, B. Yu, Y. Hui,

Tetrahedron Lett

1998

, 39, 6511-6514

10

2

Synthesis of diosgenyl alpha-L- rhamnopyrano-syl-(1® 2)-[beta-D- glucopyranosyl-(1® 3)]-beta-D- glucopyranoside  (Gracillin) and related saponins.

C. Li, B. Yu, M. Liu, Y. Hui

Carbohydr. Res

1998

, 306, 189-195

7

3

 Chemical synthesis of 2’-O, 3’-O- glycosylated diosgenyl beta-D- glucopyranosides

C. Li, B. Yu, Y. Hui

J.Carbohydr. Chem

1999

, 18, 1107-1120

3

4

 First total synthesis of Tricolorin A

S. Lu, Q. Ouyang, Z. Guo, B. Yu, Y. Hui

Angew. Chem.; Int. Engl. Ed

1997

, 36, 2344-2346

 10

5

 

Total Synthesis of Tricolorin A

S. Lu, Q. Ouyang, Z. Guo, B. Yu,

Y. Hui

J. Org. Chem

1997

, 62, 8400-8405

 

16

6

Ferrous ion induced cleavage of the peroxy bond in qinghaosu and its derivatives and the DNA damage associated with this process.

W. Wu,Z. Yao, Y. Wu, K. Jiang,Y. Wang,H.Chen, F. Shan,Y.LI

 

Chem.Commun.

1996

2213-2214

,

 

13

7

Synthetic studies toward mono-THF annona-

ceous acetogenins,an enantioselective and convergent approach to corossolone and (10RS)corossoline

Z. Yao,    Y. Wu,

J.Org.Chem.

1995

,60,

1170-1176

 

30

8

Unified Mechanistic Framework for the Fe(II)-Induced Cleavage of Qinghaosu and Derivatives/Analogs. The First Spin- Trapping Evidence for the Previously Postulated Secondary C-4 Radical

W. Wu,Y. Wu,Y. Wu,Z. Yao,C. Zhou,Y. Li,F. Shan

J. Am. Chem. Soc

1998

,120, 3316-3325

 

41